Extraordinary extended lampbrush chromosomes with thousands of transcription loops are favorable objects in chromosome biology. Chromosomes become lampbrushy due to unusually high rate of transcription during oogenesis. However, until recently, the information on the spectrum of transcribed sequences as well as genomic context of individual chromomeres was mainly limited to tandemly repetitive elements. Here we briefly outline novel findings and future directions in lampbrush chromosome studies in the post‐genomic era. We emphasize the fruitfulness of combining genome‐wide approaches with microscopy imaging (...) techniques using lampbrush chromosomes as a remarkable model object. We believe that new data on the spectrum of sequences transcribed on the lateral loops of lampbrush chromosomes and their structural organization push the boundaries in the discussion of their biological role. Also see the video abstract here: https://youtu.be/zexoHfzX9rM. (shrink)

I FORMS AND PROBLEMS OF CULTURE INTEGRATION AND METHODS OF THEIR STUDY I. Culture Integration And Culture Unity — A Dark Problem Is every culture an ...

The article characterizes the substantial level of sacralization of values in the spiritual culture of the Greater Altai. The main emphasis is placed on identifying the grounds for the sacralization of values. It is established that the world order is one of the bases of sacralization and simultaneously performs the function of consolidating cultural carriers. The key thesis of the research is the thesis that spiritual culture cannot be fully comprehended without reference to sacred values. In addition, the sacralization of (...) values is considered as a condition for ensuring spiritual security and continuity of values and norms between generations of cultural carriers. The assessment of the spiritual potential of the culture of the Greater Altai is of great importance. The main conclusions of the study are the following provisions: 1) the sacralization of key values is carried out at the essential or substantial level, while the stages of sacralization are mainly "tied" to the religious and mythological development of culture and its value-normative system; 2) sacralization encompasses those value structures that acquire importance in human existence and are a factor in the integration of cultural carriers and their generations; 3 sacralization is the process of identifying specific value-semantic structures – they are attributed symbolic meaning, and they are also correlated with certain cultural codes, signs and texts. (shrink)

Il'in's classic work is the most impassioned and cogent work by a Russian jurist on the rule of law. The product of nearly four decades of labor, which could not be published in the former Soviet Union, this revised edition places the work in the context of developments since its first English translation in 2013. The text is accompanied by one of Il'in's early and influential articles on law and power, a bibliography devoted to his life and work, and informed (...) introductory essays about his contribution to the rule of law dialogue, the origins and transformations of the concept of legal consciousness and the fascinating history of his treatise on that subject. x, 403 pp. Ivan Aleksandrovich Il'in (Доктор государственных наук) [1883-1954], sometime professor, Moscow Lomonosov State University, is one of the most widely-read legal philosophers of the twentieth century in post-Soviet Russia. William E. Butler is the John Edward Fowler Distinguished Professor of Law, Penn State Dickinson Law; Emeritus Professor of Comparative Law, University College London; and author of numerous works on post-Soviet legal systems, including Russian Law and Legal Institutions (3d ed.; 2021). Philip T. Grier, who has written extensively on Hegel and Il'in and translated Il'in's principal treatise on Hegelianism, is the Emeritus Thomas Bowman Professor of Philosophy and Religion at Dickinson College, Carlisle, Pennsylvania. Paul Robinson is a professor at the University of Ottawa. (shrink)

This paper is focused on the ways of expressing trust and distrust in financial institutions represented in the language and speech culture of the population of the Lipetsk region. Based on 55 semi-structured interviews of three generations (centennials, millennials, elder generations) living in rural and urban settlements, issues of understanding and interpretation of financial institutions, features of trust, positive and negative experiences of interaction with various financial institutions were analyzed. The use of the constructivism made it possible to interpret trust (...) as an internal component of the practices of an agent involved in the current financial situation. The study showed that in regions with an average standard of living, an average level of financial culture and the dominance of a conservative model of financial behaviour, the difference between generations is less noticeable against the backdrop of a significant difference between residents of rural and urban settlements. The analysis of interviews with three generations of residents of the region showed that the conservative model of financial behaviour continues to be reproduced in the speech culture of the informants, where banks and insurance organizations remain the most trustworthy. The images of financial institutions, represented in the language of the interviews, revealed a high level of resentment associated with the experience of past events (the collapse of the USSR, privatization). The content analysis revealed the image of the state as a “collector of payments”, and to a lesser extent, a “helper” supporting a person in his relationship with financial institutions. (shrink)

The article pays special attention to the identification of the heuristic potential of theoretical and methodological approaches to the study of spiritual culture, which has a pronounced ethnoregional specificity. In this case, we mean the spiritual culture of the Greater Altai. A value-normative approach and a systematic approach are considered, and other research perspectives are evaluated. The key point is to assess the possibilities of applying an interiorization approach that allows us to present a specific ethno-regional culture in its integrity (...) and unity of meanings. This approach is proposed to be used to study the processes of sacralization and symbolization of human individual and collective existence, occurring through the experience of cultural bearers. This perspective of the study is aimed at conceptualizing experience, but also involves an appeal to traditions, rituals, religion and mythology. However, their analysis is carried out precisely through an assessment of experience. The main methodology of the research is related to the need to present the ethnoregional culture of the Greater Altai in its value-semantic and holistic development. The main results of the study are the following provisions formulated in the article: 1) the problematization of the study of ethnoregional culture unfolds in the direction of its value-semantic reception, which implies the use of an appropriate angle of study; 2) the specificity of ethnoregional culture is formed not only in the ratio of its traditional values and norms, but also in establishing the foundations of its integrity and consistency, therefore, for analysis, such an approach is important, which allows you to reveal these points; 3) to assess the identity of culture, its systemic integrity, it is necessary to use an interiorization approach aimed at identifying the trinity of God - World - Man in the spiritual culture of the Greater Altai; 4) the social and existential experience of cultural bearers, and not only, for example, religion and mythology, should be the subject of research within the framework of the proposed interiorization the approach. (shrink)

The subject of the research in this article are certain aspects of the "philosophy of culture" of the prominent thinker, theologian, historian of Russian thought Georgy Vasilyevich Florovsky, which influenced the evolution of his worldview. Special attention is paid to the facts of the "European" period of his biography, the analysis of his "Eurasian" works, as well as his assessments of the philosophical concepts of some Russian thinkers and calls for the conversion of the process of cultural creativity to spiritual (...) principles. Particular attention is paid to the content of the discussion that unfolded between G.V. Florovsky, N.S. Trubetskoy and (in absentia) N.Ya. Danilevsky on the problem of the status of "universal culture" and the mutual influences of cultures. The study reveals the philosophical nuances of the evolution of G. Florovsky's views as a "Eurasian" author based on his own works and the assessments contained therein. Scientific literature often emphasizes the influence of Eurasian ideology on G. Florovsky, expressed, in particular, in his ideas about culture and cultural creativity. However, based on the analysis of the material presented in the article, the author comes to the conclusion that G.V. Florovsky, although he was a member of the Eurasian circle, on some significant issues differed from the main direction of development of the Eurasian ideology presented by E. Trubetskoy. (shrink)

The modern world is confronted with a series of global problems, exacerbated by technological advancements. In this context, concerns arise in the public consciousness regarding the potential of artificial intelligence (AI) to surpass humans in intellectual and creative activities. The topic of AI creativity becomes pertinent and sparks debates within the scientific community regarding its creative potential. In response to these challenges, members of the Club of Rome in 2018 propose the concept of a new Enlightenment and the principle of (...) balance as a response to the demands of technological development. These ideas underscore the need for a balanced approach to technical progress, taking into account global values and ethical principles. I explore the definitions of creativity and AI, formulate criteria for assessing creativity, and analyse recent achievements in modelling creative processes in AI. I also focus on the utilisation of various algorithms for implementing diverse forms of creative activities, including text, image and music generation. Additionally, I present diverse opinions of researchers regarding creativity in AI. To systematise these perspectives, I propose a classification which allows their ranking. The conclusion emphasises that currently the issue of evaluating the creative potential of AI lacks a definitive solution, underscoring the relevance of further research. The future outlook may alter this situation, prompting the necessity to focus on predicting potential consequences of technological developments and developing mechanisms for controlling AI activities; humans, after all, bear responsibility for AI actions. Such an approach aligns with the concept of a new Enlightenment which seeks a balance between technological advancements and the preservation of global harmony. (shrink)

The objective of this study is to identify inimitable examples of the introduction of aesthetic content into the Western European metaphysical tradition, as it was embodied in Kant's understanding of the world concept of philosophy, which has certain aesthetic connotations. In the article, the author analyzes new stages of the movement towards the world concept of philosophy, on which the aesthetic meaning of the basic structures of transcendentalism is explicitly or implicitly realized: the art of schematism as a world concept (...) of epistemology; the world concept of art as an organ of understanding artistic works. In addition, this discussion becomes particularly relevant when they seek to reveal how much the concept of schematism allows us to advance to the explanation of the world concept of philosophy. The work reveals how Kant reproduces the definition of the world concept of philosophy according to a certain model, while posing the problem of the typical embodiment of the idea, the ideal of the philosopher as a model. In this connection, a new complication of aesthetic analysis is being carried out in order to show how the world concept of philosophy was personified and presented as if in the ideal of the philosopher as a model. Therefore, the paradox of the world concept of philosophy lies in the fact that we have to talk about a sample of what does not yet exist. The author reproduces a transcendental language that will reveal the movement of aesthetic thought into the center of the world concept of philosophy, where the traditional artistic technique of personification of the philosopher's ideal as a model is performed, where the contemplation of meaning is transferred into the universality of the concept, into the contours of metaphysics. (shrink)

The aim of the study is to clarify the aesthetic concept of color perception from the phenomenological reasoning of Edmund Husserl. Today, the orientation diagram of the field of phenomenological research is formed in various zones: from theological to naturalistic. In which of these zones the structures of the phenomenological analysis of color are located is not an easy question. The coloristic region is constituted according to the degree of consciousness, including aesthetic consciousness. It is extremely difficult to meet with (...) the phenomenon of color, if only because its obviousness is fulfilled only by the fervor of the contemplative consciousness with its aesthetic pathos, a consciousness that distinguishes between, as it were, the reality of transcendent color and the aesthetic "continent of givens". We are talking, as Husserl would say, about the halo of consciousness, referring to the essence of perception performed in the mode of turning to the beauty of color. For the first time, approaches to the study of such a complex phenomenological topic as the description of a coloristic attitude, the eidetics of color experiences in Husserl's philosophy are outlined, the significance of its development for the comprehension of aesthetic and artistic consciousness is revealed. The main conclusions of the study are related to the philosophical interpretation of the idea of color as included in phenomenology in the experience of philosophical surprise, which turns into the acquisition of the essence of "phenomenological color" in general, and in aesthetics it is directly correlated with the appearance of its structures on the horizon of the harmonic synthesis of acts of perceptual performance in the imagination, "primordial giving visions" of color, with the creation of a picture coloristic impressions as cognitive emotions, reduced pure color perception, with an understanding of how art makes the very conditions of color visibility obvious, how its artistic synthesis is made, in the structure of which correlation analysis can see an analogue of a priori empiricism – this fundamental characteristic of purely Husserl synthesis and method revealed in domestic studies. (shrink)

V glavakh kollektivnoi| monografii predstavleny kont︠s︡eptualʹnye razrabotki problem, znachimykh dli︠a︡ filosofii nachala novogo stoletii︠a︡. Ėtot krug problem okhvatyvaet vse oblasti sovremennoi| filosofii--ot ontologii i filosofii nauki do filosofii logiki i politiki. Sovremennye ot︠s︡enki i razvitie poluchai︠u︡t idei analiticheskoi| filosofii, ėkzistent︠s︡ializma, fenomenologii, strukturalizma s ikh orientat︠s︡iei| na prikladnye sfery. Kniga adresovana kak spet︠s︡ialistam, tak i vsem tem, kto proi︠a︡vli︠a︡et interes k sostoi︠a︡nii︠u︡ i problematike sovremennoi| otechestvennoĭ filosofii.